New research from the Shabek laboratory at UC Davis unravels a new regulatory function of ubiquitin ligase in plant signalling. We combined structural biology, biochemistry and in planta CRISPR/Cas9 genome editing to show that the conformational switch in ASK1-D3/MAX2 CTH directly regulates the ubiquitin-mediated protein degradation process in strigolactone signaling pathway. We have also uncovered an organic acid metabolite that can directly trigger conformational switch. Congratulations to Lior Tal, Malathy Palayam and Alec Young from the Shabek lab!!! www.nature.com/articles/s42003-022-03085-6