Congratulations to Alex Kehl, an undergraduate student researcher in the Shabek lab, for being accepted into the UC Davis Maximizing Access to Research Careers/Biology Scholars Advanced Research Program (MARC/BSHARP)! The MARC/BSHARP program provides support and intensive research experience to exceptional undergraduate students from disadvantaged or underrepresented backgrounds. As part of this program, Alex will be…
Congratulations to Dr. Shabek and the Zheng lab at UW on their paper “Structural insights into DDA1 function as a core component of the CRL4-DDB1 ubiquitin ligase,” published today in Cell Discovery (Nature).
Dr. Shabek’s work demonstrating structural plasticity of the D3–D14 ubiquitin ligase in strigolactone signaling is published in Nature! These findings reveal how D3 can utilize two distinct structural states to control strigolactone signaling. In its closed form, D3 binds to inactive D14. However, in its open conformation, D3 binds to hormone-bound D14 to enable strigolactone…