Nitzan Shabek, Ph.D.
University of California, Davis
College of Biological Sciences
Plant Biology Department
Postdoctoral Fellow – HHMI, University of Washington
Ph.D. – Technion- Israel Institute of Technology
Before joining UC Davis, I was a postdoc at the University of Washington in Seattle, where I worked with Dr. Ning Zheng on elucidating how target proteins can be recognized by ubiquitin ligase enzymes. Using various biochemical and cellular approaches together with X-ray crystallography, I studied the regulation, composition, and structure of specific biosensor protein complex in plant hormone signalling. Prior to that, I obtained my Ph.D. in Biochemistry at the Technion- Israel Institute of Technology with the mentorship of Dr. Aaron Ciechanover (Nobel Laureate in Chemistry). My Ph.D. research focused on understanding the mechanistic regulation of cellular ubiquitin pools and protein recognition and degradation by 26S proteasome. I have also studied the yeast’s DNA endonuclease proteolytic regulation by ubiquitin-like proteins, and obtained my M.Sc. from the Ben-Gurion University.
My research experience spans both theoretical and applied work, in the areas of structural biology, biochemistry, cellular and molecular biology (in bacteria, yeasts, insects, plants and mammalian). I am broadly interested in how certain signals are perceived, transduced and regulated in cells, and how biological pathways are controlled by proteolytic systems. My research goal is to envision these biological pathways from atomic to organismal level and address pathophysiological challenges through bioengineering.
In my spare time, I love spending time with my family, hiking, biking, cooking and shredding on my electric guitar.