How is a physical stimulus (such as light, gravity, hormones, and metabolites) perceived and integrated into a signal transduction pathway, and how are these cellular events regulated by the proteolytic machinery?  Our research integrates cutting edge approaches from the fields of biochemistry, structural biology, and molecular and cellular biology to decode these sensing machineries and signaling pathways in plants, fungi, and humans.

Our ultimate goal is to decipher fundamental biological pathways from the atomic to organismal level, and develop innovative strategies for the benefit of agriculture, environment, and human health.